Effect of The Combination of Kefa Forest Honey and Euphorbia hirta as a Curative agent of Vibrio alginolyticus in the Hybrid Grouper Epinephelus fuscoguttatus

Abstract Kefa forest honey and Euphorbia hirta have an antibacterial effect against pathogenic bacteria in fish. This work investigated the combination of E. Vibrio alginolitycus hybrid grouper Epinephelus fuscoguttatus . The active ingredients activity were tested vitro at different concentrations using disk method. experimental animals injected with V. suspension a concentration 10 6 cells ml −1 /fish. After fish showed symptoms infection, treatment was carried out for 5 consecutive days by immersion mixture 25% combinations. treatment, monitored 7 days. During study, observations on hematology clinical made. results that had vivo can increase hematological profile alleviate due to infection. administration effective as cure alginolyticus infection grouper.